^(99m)Tc-甲酯异丙基异腈心肌灌注单光子断层显像诊断冠心病的临床研究

CLINICAL EVALUATION OF ^(99m)Tc-CPI MYOCARDIAL PERFUSION SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHY IN THE DIAGNOSIS OF CORONARY HEART DISEASE

本文利用^(99m)Tc-甲酯异丙基异腈作为心肌灌注显像剂,对2例正常人、5例陈旧性心肌梗塞患者和4例心绞痛患者进行了14次心肌灌注单光子断层显像.结果2例正常人静息断层右室不显像,左室显像清晰,心肌放射性分布均匀.9例患者均见左室心肌放射性分布呈局限性或多发性稀疏或缺损.经与选择性冠状动脉造影、超声心动图、动态心电图和心电图运动试验等检查比较,表明该方法诊断心肌缺血或坏死与选择性冠状动脉造影具有高度一致性,且较超声心动图、动态心电图和心电图运动试验等敏感.

Two normal subjects,5 patients with old myocardial infarction(OMI) and 1 patients with angina pectoris were examined by rest single photon emission computerized tomography (SPECT) with ^(99m)Tc-CPI. Our data revealed that the right ventricular was not imaged, the left ventricular was well exposed in the normal subjects. All the 9 patients had defects in the left ventricle. Comparison of SPECT with ^(99m)Tc-CPI with selective coronary arteriography(SCA), echocardiography(UCG),dynamic electrocardiography(DCG) and electrocardiographic(ECG)-exercise test in the diagnosis of myocardial ischemia or necrosis has demonstrated the former to be more significantly sensitive than the latter four. Good agreement between SPECT and SCA has been confirmed.