左心室舒张末期顺应性与舒张功能障碍机理研究

RELATIONSHIP BETWEEN LEFT VEN-TRICULAR END DIASTOLIC COMPLIANCE AND ABNORMAL DOPPLERMITRAL FILLING

冠状动脉病变合并高血压患者19例,正常对照10例,分别以心导管和Doppler超声心动图方法作了左心室舒张末期顺应性(LVEDC)和二尖瓣跨瓣血流速度检测.结果病变组LVEDC较对照组降低(P<0.01),与Doppler舒张晚期血流峰值速度(PVA)增高等异常舒张功能同时出现.此外,对照组PVA随LVEDC增高而降低(P<0.05),病变组则不明显,提示在舒张功能不全的发生中除了LVEDC降低机制外,尚有其它因素参与.

Left ventricular end-diastolic compliance (LVEDC) and transmitral flow velocities were measured respectively by means of LV catheterization and pulsed-Doppler echocardiography in 19 patients with coronary artery disease associated with hypertension and 10 normal subjects. The LVEDC was much lower in patients than in normal subjects (P<0.01). The data showed that abnormal Doppler diastolic function such as elevated late diastolic peak flow velocity (PVA) and decreased LVEDC occurred simultaneously in these patients. In addition, the negative correlation of PVA with LVEDC observed in the normal controls but not in the patients suggested that in patients with impaired diastolic filling, other factors as well as the decreased LVEDC itself must have jointly participated in the development of diastolic dysfunction.