老年阿尔茨海默病患者血中脂多糖结合蛋白水平测定

Determination of blood lipopolysaccharide binding protein levels in elderly patients with Alzheimer’s disease

目的:探讨血中脂多糖结合蛋白(lipopolysaccharide binding protein, LBP)在老年阿尔茨海默病(Alzheimer’s disease, AD)患者与正常老年对照组中的水平差异。方法:选择老年AD与正常老年对照各22例,采用简明精神状态检查量表(Mini-Mental State Examination, MMSE)评价两组人群认知功能,LBP试剂盒检测两组人群LBP含量。结果:正常老年对照组MMSE得分为28.15±3.4,AD患者组为1.05±1.73。正常老年对照组血中LBP含量为(94.82±61.05)ng/mL,AD患者组为(169.39±87.79)ng/mL。2组人群认知功能以血中LBP水平均具有显著差异(P<0.05)。结论:AD患者血LBP含量明显高于正常老年对照。老年AD患者血中LBP水平的升高可能与AD的发生发展具有一定相关性。

Objective To investigate the difference in levels of lipopolysaccharide binding protein(LBP)in elderly patients with Alzheimer’s disease(AD)and normal elderly controls.Methods elderly patients with AD and normal elderly controls(22 cases each)were enrolled.The cognitive function of the two groups was evaluated by the Mini-Mental State Examination(MMSE)and the blood LBP level of the two groups was detected by LBP kit.Results The MMSE score of the normal elderly group was 28.15±3.4,and that of the AD group was 1.05±1.73.The blood LBP content in the normal elderly control group was(94.82±61.05)ng/mL,and which in patients with AD was(169.39±87.79)ng/mL.The cognitive function and blood LBP level between the two groups were significantly different(P<0.05).Conclusion The blood LBP content of AD patients was significantly higher than that of normal elderly controls.The increase of blood LBP level in elderly AD patients may be related to the occurrence and development of AD.