速肿消注射液毒性研究

STUDY ON THE TOXICITY OF SU ZHONGXIAO INJECTION

为提供速肿消注射液的安全性毒理学评价资料，本试验采用改良Ｋａｒｂｅｒ法测定小鼠ＬＤ５０；以剂量递增法测定小鼠蓄积性和耐受性；分别以剂量 ５００、２００、１００ｍｇ／ｋｇ为３个试验组，设阴性和阳性对照组进行小鼠骨髓微核试验；分别以剂量 ７５０、３７５、１８８ ｍｇ／ｋｇ为３个剂量组，设阴性和阳性对照组进行小鼠精子畸形试验。结果表明：其ＬＤ５０为９９４．７２ ｍｇ／ｋｇ，蓄积系数大于５．３，无显著积毒性和耐受性（Ｐ＞０．０５），小鼠骨髓微核试验和精子畸形试验结果均为阴性。

In order to provide some scientific data for safety evaluation of WU ZHONG XIAO injection this paper detemines LD50;by improved karber method,accumulative toxicity by progressive dose increase method,bone marrow micronucleus test with3 experimental groups at dosage of 500,200 and 100mg/kg respectively and positive and negative control groups, spermatogenic malformative test with 3 experimental groups at dosage of 750,375 and 188 mg/kg respectively and positive and negative control groups. It also determines the tolerance. Experimental animals used in these 5 tests are mice. The data are 994 .72 mg/kg and over 5. 3(accumulative coefficient). The other 3 results are all negative.