中枢乙酰胆碱与针刺镇痛关系的研究

RESEARCH ON THE RELATIONSHIP BETWEEN CENTRAL ACETYLCHOLINE AND ACUPUNCTURE ANALGESIA

乙酰胆碱(Ach)不论在种系发生或个体发生上都是最早出现的神经递质,在某些低等动物感觉传入神经全部是胆碱能的,高等动物痛觉的神经通路有一部分也和上行胆碱能网状激活系统一致;脑内一些重要的与痛和镇痛有关的结构是胆碱能的;因此我们认为 Ach

The artical systematically reported our physiological and biochemical work on the relationship between central acetylcholine and acupuncture analgesia. The results indicate: 1.Acupuncture on acupoints could produce analgesia. 2.Ach contents in cerebrospinal fluids and brain increased under acupu- ncture analgesia. 3.AChE activities iu brain elevated under acupuncture analgesia. 4.ChE inhibitor reinforced the effects of acupuncture and inhibitor of ACh synthesis could inhibit the effects of acupuncture,which could be reversed by administration of ACh and chlorocholine.M-AChR antagonists could also inhibit the effects of acupuncture. 5.The turnover rate of ACh in diencephalon,caudate nucleus and spinal dorsal horn accelerated when acupuncture analgesia. The discussion was given on the variation of metabolic dynamics in co- mbination with related literature.