嗜海洛因者海绵状白质脑病SPECT脑灌注显像10例临床分析

Single photon emission computerized tomography of spongiform leukoencephalopathy heroin addicts: analysis of 10 cases

目的 了解嗜海洛因者海绵状白质脑病的脑循环改变。方法 利用单光子发射计算机断层扫描仪对10例嗜海洛因致海绵状白质脑病患者进行脑血流灌注断层显像。结果 10例均见幕上及小脑白质区不同程度扩大,白质放射性减低或缺损,双侧对称;灰质可见局灶性多发性血流灌注减低。结论 海洛因海绵状白质脑病患者脑白质血流量降低,脑的灰质亦不同程度受到波及。

Objective To investigate the changes in cerebral circulation in heroin addicts with pongiform leukoencephalopa-thy. Methods Single photon emission computerized tomography (SPECT) was performed in 10 such patients. Results Regional cerebral blood flow (rCBF) in the involved white matter of bilateral cerebral and cerebellar hemispheres was obviously reduced. rCBF of temporal lobes, parietal lobes, cerebellar hemispheres and basal ganglion were reduced in varying degrees. Conclusion As demonstrated by the result of SPECT, rCBF in the white matter of bilateral cerebral and cerebellar hemispheres was reduced with partial involvement of the gray matter of heroin addicts with spongiform leukoencephalopathy.