CHOP-PVP与CHOP方案治疗非霍奇金淋巴瘤的疗效比较

Retrospective comparison between CHOP-PVP and CHOP protocols for non-Hodgkin′s lymphoma

目的 比较CHOP PVP与CHOP方案治疗非霍奇金淋巴瘤 (NHL)的疗效。方法 79例NHL患者采用CHOP PVP方案治疗 4 0例 ,采用CHOP方案治疗 39例。采用Kaplan Meier方法分析患者治疗后的生存期 ,采用Cox比例风险模型分析影响预后的因素。结果 CHOP PVP方案组完全缓解率 5 7.5 % (2 3/ 4 0 ) ,总有效率 87.5 % (35 / 4 0 ) ;CHOP方案组完全缓解率 33.3% (13/ 39) ,总有效率 6 9.2 %(2 7/ 39)。两组完全缓解率差异有显著性 (P <0 .0 5 ) ,总有效率差异有显著性 (P <0 .0 5 )。两组患者的主要毒副反应为骨髓抑制。白细胞下降CHOP PVP组为 82 .5 % ,CHOP组为 71.8% (P >0 .0 5 ) ,但均无Ⅳ度下降发生 ,亦无与毒性有关的死亡发生。结论 CHOP PVP方案具有有效率高、副反应无明显加重的优点 ,可替代经典的CHOP方案治疗NHL。

Objective To compare the therapeutic effects between CHOP PVP and CHOP protocols for non Hodgkin′s lymphoma (NHL). Methods Of 79 NHL patients, 40 received CHOP PVP and 39 received CHOP protocol. Kaplan Meier method was used for survival rate and Cox regression model for prognostic factors. Results The complete remission rate and overall response rate were 57.5% (23/40) and 87. 5% (35 /40) in CHOP PVP group and they were 33.3% (13/39) and 69.2% (27/39)in CHOP gro up. There was a significant difference ( P < 0.05) in the complete remission r ate and overall response rate between the two groups. The main toxicity was myelosu ppression. The leukocytopenia rate was 82.5% in CHOP PVP group and 71.8% in CH OP group ( P > 0.05) with no fatality in either group. Conclusion CHOP PVP protocol may be more effective for non Hodgkin′s lymphoma than CHO P protocol without increasing toxicity.