水蛭注射液治疗糖尿病周围神经病变的疗效观察

Therapeutic effect of Hirudo injection on diabetic peripheral neuropathy

目的 观察水蛭注射液治疗糖尿病周围神经病变的临床疗效。方法 糖尿病周围神经病变 62例患者随机分为 2组。治疗组 40例用水蛭注射液维生素B1 ,维生素B1 2 治疗 ,对照组 2 2例单纯使用维生素B1 、维生素B1 2 治疗。 2组均 30日为 1个疗程 ,2个疗程后统计疗效 ,并观察 2组治疗前后肌电图、血液流变学、空腹血糖、糖化血红蛋白的变化。结果 治疗组显效率为 35 .0 % ,总有效率为 80 .0 % ;对照组无显效者 ,总有效率为 36.4%。 2组比较均有显著性差异 (P <0 .0 5 )。治疗组治疗前后血流变学有明显改善 (P <0 .0 5 ) ,对照组则无明显变化 (P >0 .0 5 ) ,2组治疗后比较有显著性差异 (P <0 .0 5 )。 2组治疗前后空腹血糖、糖化血红蛋白无明显变化 (P >0 .0 5 )。

Objective To observe the therapeutic effect of Hirudo injection on diabetic peripheral neuropathy .Methods Sixty-two patients with diabetic peripheral neuropathy were randomly divided into two groups.40 patients in treatment group were treated by Hirudo injection;22 patients in control group were treated simply by vitamin B 1 and vitamin B 12 , with a treatment course of 30 days for both groups.The therapeutic effect was evaluated after two courses. The electromyogram (EMG) before and after treatment,hemorrheology, fasting blood glucose (FBS),glycosylated hemoglobin for both group were observed.Results The marked effective rate in treatment group was 35.0%.The total effective rate was 80.0% in treatment group and 36.4% in control group,there was a significant difference between the two groups (P<0.05).The hemorrheology before and after treatment in treatment group was improved remarkably (P<0.05),while that in control group was not (P>0.05).There was no significant difference in FBS and glycosylated hemoglobin between the two groups (P>0.05).Conclusion Hirudo injection has definite therapeutic effect on diabetic peripheral neuropathy .