拟血管性痴呆小鼠血浆血栓素B_2、6-酮-前列腺素F_1α的变化及电针的影响

The effect of the electropuncture on the plasma TXB_2、6-Keto-PGF1α content in synthetic vascular dementia mouse

目的 观察拟血管性痴呆小鼠血浆血栓素B2 (TXB2 )、6 酮 前列腺素F1 α( 6 Keto PGF1 α)的变化及电针的影响 ,探讨针刺治疗血管性痴呆的作用机制。方法 复制脑缺血再灌注拟血管性痴呆小鼠模型 ,电针肾俞、膈俞、百会穴 ,与药物喜德镇对照 ,分别于术后 7、1 5、30日 ,检测血浆TXB2 、6 Keto PGF1 α含量。结果 该造模方法对小鼠的TXB2 、6 keto PGF1 α 2项指标未见明显影响 ,电针可使正常小鼠 6 Keto PGF1 α含量在术后 1 5日与 30日均明显升高。结论 电针可提高正常小鼠抗血小板聚集、扩血管能力 ,此可能为针刺治疗血管性痴呆的作用途径之一。

Objective To observe the effect of the electropuncture and the change of plasma TXB 2?6 Keto PGF 1α content in synthetic VD mouse, to study the function mechanism of treating VD with acupuncture. Methods Duplicated re perfusion synthetic VD mouse model of cerebral ischemia, electropunctured Shenshu, Geshu and Baihui, compared with Hydergine after 7 days, 15 days and 30days and then assayed plasma TXB 2 and 6 Keto PGF 1α content. Results The model making method had no obvious effect on mice's plasma TXB 2 and 6 Keto PGF 1α content. Electrical acupuncture could obviously elevate the normal mice's 6 Keto PGF 1α content at the 15 and 30 days after the operation. Conclusion Electrical acupuncture could improve the normal mice's ability of anti platelet aggregation and extending the blood vessel, which might be one of the mechanisms of treating VD with acupuncture.