消栓肠溶胶囊对急性脑梗死侧枝循环的影响研究

Clinical research of Xiaoshuan enteric Capsule for the treatment of acute cerebral infarction

目的:观察消栓肠溶胶囊对急性脑梗死患者侧枝循环的影响,以探讨其治疗急性脑梗死的作用机制。方法:选取急性脑梗死患者68例,随机分为消栓肠溶胶囊组35例和对照组33例,对照组予以标准化治疗,消栓肠溶胶囊组在标准化治疗基础上加用消栓肠溶胶囊,连用14d后,通过经颅多普勒超声(TCD)观察治疗后颅内动脉血流动力学的改变,并结合NIHSS评分观察其临床疗效。结果:消栓肠溶胶囊组供血动脉的血流改善例数增加,与对照组比较有明显差异;消栓肠溶胶囊组NIHSS评分明显低于对照组。结论:消栓肠溶胶囊治疗急性脑梗死能促进侧支循环的建立,改善梗死区及缺血区域血流情况而达到改善其临床症状。

Objective: To observe the effect of Xiaoshuan enteric capsules in the treatment of the patients with acute cerebral collateral circulation, and to investigate the possible mechanism. Methods: 68 cases with acute cerebral infarction were randomly divided into the Xiaoshuan enteric capsules group 35 cases and 33 cases in the control group. The control group received standard treatment, meanwhile the enteric capsules Xiaoshuan was applied as addition based on the standard treatment. After once a 14 d, arterial hemodynamics was observed by Transcranial Doppler(TCD) and NIHSS score was done to evaluate the clinical effect. Results: The cases of improving feeding arteries blood flow increased in the Xiaoshuan enteric capsules group, there were significant differences between the control group; Xiaoshuan enteric capsules group NIHSS score was significantly lower than the control group. Conclusion: Xiaoshuan enteric capsule in treatment of acute cerebral infarction can promote the establishment of collateral circulation, improve the infarct region and ischemic blood flow to achieve improved clinical symptoms.