联合抗血小板方案辅助治疗急性脑梗死临床研究

Clinical study of combination anti-platelet therapy in the treatment of acute cerebral infarction

目的:探讨联合抗血小板方案辅助对症干预治疗急性脑梗死临床效果。方法:选取急性脑梗死患者共80例,以随机区组法分为对照组(40例)和联合组(40例),分别在对症干预基础上给予阿司匹林单用和阿司匹林+氯吡格雷联合抗血小板治疗;比较两组患者近期疗效、治疗前后NIHSS评分及脑血管不良事件发生率等。结果:联合组患者近期疗效和治疗NIHSS评分均显著优于对照组,差异有统计学意义(P<0.05);同时联合组患者脑血管意外事件发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:联合抗血小板方案辅助对症干预治疗急性脑梗死可有效保护受损神经功能,降低脑血管意外发生风险,具有临床应用价值。

Objective:To investigate the clinical effects of combination anti-platelet therapy in the treatment of acute cerebral infarction.Methods:80 patients with acute cerebral infarction were chosen and randomly divided into two groups including control group(40 patients) with aspirin used alone and combined group(40 patients) with aspirin combined with clopidogrel; and the recent clinical effect, the NIHSS score before and after treatment and the incidence of cerebrovascular adverse events of both groups were compared.Results:The recent clinical effect and the NIHSS score after treatment of combined group after treatment was significant better than control group(P<0.05). The incidence of cerebrovascular adverse events of combined group after treatment was significant lower than control group(P<0.05).Conclusion:Combination anti-platelet therapy in the treatment of acute cerebral infarction can efficiently protect the damaged nerve function and reduce the risk of cerebral vascular accident.