进展性脑梗死患者相关凝血指标分析

The changes of D-dimer,fibrinogen and fibrinogen degradation product in progressing ischemic stroke

目的探讨进展性脑梗死与血浆D-二聚体(D-D)、纤维蛋白原及其降解产物含量的关系。方法采用免疫比浊法测定血浆D-二聚体和纤维蛋白原,乳胶凝聚法测定纤维蛋白原降解产物(FDP)含量。比较进展性脑梗死、非进展性脑梗死及健康对照组之间的差异。结果脑梗死组在D-二聚体、纤维蛋白原及其降解产物含量明显高于健康对照组,与之比较差异有统计学意义(P<0.05),进展性脑梗死高于非进展性脑梗死(P<0.05)。结论进展性脑梗死患者存在着明显的高凝状态,这与其发生及病情进展密切相关。

Objective To observe the plasma levels of D-dimer(D-D)and fibrinogen(Fib)in progressing ischemic stroke.Methods The D-D and Fib level were determined by immunotur-bidimetry.Compare with the D-D and Fib level in Progressing Ischemic Stroke,not Progressing Ischemic Stroke and control group.Results D-D and Fib contents in ischemic stroke group were significantly higher than those in control group(P<0.05 ).D-D and Fib contents in Progressing Ischemic Stroke group were higher than those in not Progressing Ischemic Stroke group,D-D and Fib contents in not Progressing Ischemic Stroke were higher than those in control group(P<0.05 ).Conclusion There is a high coagulative satuation in Progressing Ischemic Stroke.It is positive correlation between them.