首发抑郁症患者治疗前后工作记忆的研究

Investigation of working memory function in first-episode patients with depressive before and after therapy

目的研究首发抑郁症患者治疗前后工作记忆变化。方法选取30例首发型抑郁症患者(患者组)以及与其人口学资料相匹配的30例健康对照组作为研究对象,采用字母2-Back任务进行工作记忆的测试。结果 1患者组治疗前在正确率和反应时[(66.39±7.06)%;(1 440.85±256.69)ms]均差于对照组[(91.39±7.54)%;(1 153.92±282.35)ms],差异有统计学意义(t=-13.253,P=0.00;t=4.119,P=0.00);2患者组治疗后正确率(81.22±11.35)%要差于对照组(91.39±7.54)%,差异有统计学意义(t=-4.085,P<0.05);3治疗后患者组正确率和反应时均有明显提高(t=-6.710,P<0.05;t=4.150,P<0.05)。结论抑郁症患者治疗后工作记忆功能明显提高,但未恢复到正常水平,这种损伤可能与中枢系统激活异常相关。

Objective To explore the damaging traits of working memory function in first episode patients with depressive disorder before treatment and after treatmentl.Methods 30 patients were compared with matched 30 health controls completed the alphabet 2-Back Task that assessed the working memory function.Results ①Before treatment,Patients group with Accurate rate and reaction time of 2-back Test were significantly different with health controls [(66.39 ±7.06)%vs (91.39 ±7.54)%],[(1440.85 ±256.69)ms vs (1153.92 ± 282.35)ms](t=-13.253,P=0.00;t=4.119,P=0.00).②After treatment,Patients group with Accurate rate of2-back Test were signif-icantly different with health controls[(81.22 ±11.35)% vs (91.39 ±7.54)%](t=-4.085,P<0.05),③Accurate rate and reaction time of 2-back Test in patients group were significantly different before and after treatment (t=-6.710,P<0.05;t=4.150,P<0.05). Conclusion The working memory function improves after treatment in patients with first-episode depression,but does not reach health con-trols degree.The impairments may be related to activation abnormal in central nervous system.