帕金森病患者血清尿酸水平与临床症状的相关性研究

Relevance research between serum uric acid level of Parkinson's patients and clinical symptoms

目的研究帕金森病(PD)运动症状、非运动症状与血清尿酸水平的关系。方法选择PD患者70例,非PD患者45例为对照组,比较两组尿酸值;并对PD组进行非运动症状问卷、统一帕金森病评定量表、汉密尔顿焦虑量表、汉密尔顿抑郁量表及简单精神状态检查量表评估其临床症状,分析PD组患者临床症状与血尿酸的关系。结果 PD组较对照组血尿酸水平明显降低;PD患者血尿酸与H-Y分期,运动症状及非运动症状发生数无明显相关性;但在非运动症状中,抑郁、焦虑及认知功能障碍与血尿酸水平呈显著相关性。结论低尿酸血症可能是PD的危险因素,尿酸与PD非运动症状中抑郁、焦虑、认知功能障碍的发生密切相关,也间接证实了尿酸在PD中的神经保护性作用。

Objective To explore the clinical symptoms in patients with Parkinson′s disease ( PD) ( including motor symptoms ,non-motor symptoms ) and the relationship between serum uric acid level and clinical symptoms .Methods Seventy cases of PD patients were chosen and the other 40 patients with non-PD were as the control group .Colorimetric method was used to determine the value of serum UA . And UA value in case group and control group was compared .The motor symptoms questionnaire and unified Parkinson′s disease rating scale were used in patients with PD to assess their clinical symptoms ,and the correlation between numbers of motor and non-motor symptoms ,and the severity of disease in patients with PD group with serum uric acid were analysed .Results PD patients had lower blood uric acid levels than those in the control group .There was no obvious correlation between PD patients′serum uric acid level and H-Y in installment,motor symptoms and non-motor symptoms.However,the non-motor symptoms,depression,anxiety and cognitive dysfunction had significant correla-tions with serum uric acid .Conclusion Low uric acid levels may be a risk factor for PD ,especially great importance should be attached to the uric acid and PD in the non-motor symptoms of depression ,anxiety,cognitive dysfunction .It also indirectly confirms the nerve protective role of uric acid in PD .