红细胞体积分布宽度与冠心病的关系研究

Correlation of red blood cell distribution width with coronary heart disease

目的探讨红细胞分布宽度(RDW)与冠心病(CHD)的关系。方法选取冠状动脉造影确诊的152例CHD患者为CHD组,67例健康体检人群为对照组。对比分析两组人群的RDW、红细胞计数(RBC)、血红蛋白(HGB)、红细胞平均体积(MCV)、血细胞比容(Hct)、白细胞计数(WBC)、血小板计数(PLT)、平均血小板体积(MPV)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血肌肝(Cr)、尿素氮(BUN);采用改良Gensini积分法评价冠状动脉病变的严重程度。结果与对照组比较,CHD组RDW明显升高(P<0.05)。结论 RDW与CHD及冠状动脉病变严重程度存在一定关系,可以预测其严重程度。

Objective To assess the relation between red blood cell distribution width(RDW)and coronary heart disease (CHD).Methods A total of 152 patients with CHD by coronary angiography admitted to our hospital were assigned to coronary heart disease group, and another 67 healthy cases in hospital physical examination in the same period were selected as control group.The laboratory indicators,in-cluding RDW,red blood cell count(RBC),hemoglobin(HGB),average red blood cell volume(MCV),white blood cell count(WBC),hema-tocrit(Hct),platelet count(PLT),mean platelet volume(MPV),aspartate aminotransferase(AST),alanine aminotransferase(ALT),muscle, liver(Cr),blood urea nitrogen(BUN)of the two groups were compared.The severity of coronary artery lesions was evaluated by modified Gensini score method,and its correlation with RDW was analyzed.Results Compared with control group,RDW in CHD group increased sig-nificantly(P <0.05).Conclusion RDW is associated with CHD and the severity of coronary artery lesion,which could be a predictor for the severity of pathological changes in coronary artery.