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表皮生长因子受体抑制剂吉非替尼的研究进展 被引量:10

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摘要 表皮生长因子受体(EGFR)是一种酪氨酸激酶,促进细胞增殖和血管形成,同时在多种实体瘤中表达,与疾病进展、放化疗耐药、预后差相关联。EGFR抑制剂(EGFR-TKI)通过选择性地抑制表皮生长因子受体介导的信号传导途径,抑制肿瘤细胞凋亡。临床研究表明,EGFR-TKI在治疗肺癌、乳腺癌、卵巢癌等已经获得一定成效,其中吉非替尼是一种具有代表性的表皮生长因子受体酪氨酸激酶抑制剂,
作者 王利
出处 《安徽医学》 2015年第1期111-114,共4页 Anhui Medical Journal
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