摘要
目的探讨热休克蛋白90(HSP90)在胃癌组织中的表达及意义。方法利用免疫组化87-8973二步法,检测80例胃癌及20例癌旁正常胃黏膜组织中HSP90的表达。结果胃癌组织中HSP90的阳性率显著高于正常黏膜组织,差异有统计学意义(P<0.05)。胃癌组织中HSP90的阳性率与肿瘤分化程度、侵犯深度、淋巴结有无转移及TNM分期相关(P<0.05)。结论HSP90可能在胃癌的发生、发展和淋巴结转移中发挥重要作用。
Objective To investigate the roles of HSP90 in gastric carcinoma. Methods The expression of HSP90 was detected by 87-8973 immunohistochemical technique in 80 cases of gastric carcinoma and and their surrounding normal tissues(n = 20). Results The positive percentage of HSP90 protein expression in gastric cancer was significantly higher than that in normal gastric mucosa tissues(P <0. 05). The expression of HSP90 was significantly related with tumor differentiation,invasive depth,lymph node metastasis and TNM stage (P < 0. 05). Conclusion HSP90 may play an important role in the pathogenesis,development and lymph node metastasis of gastric carci-noma.
出处
《安徽医学》
2015年第12期1457-1459,共3页
Anhui Medical Journal
基金
南京市医学科技发展项目计划资助(项目编号:YKK13220)
南京市2013年第一批科技发展指导性计划项目(项目编号:2013ZD010)
关键词
胃肿瘤
热休克蛋白90
免疫组织化学
Gastric neopliasms
Heat - shock protein 90
Immunohistochemistry
