瑞舒伐他汀钙对急性冠脉综合征患者冠脉硬化程度及血浆NT-proBNP水平影响分析

Rosuvastatin calcium in patients with acute coronary syndrome coronary sclerosis and impact analysis of plasma NT-pro BNP levels

目的探讨瑞舒伐他汀钙对急性冠脉综合征(ACS)患者冠脉硬化程度及血浆氨基末端脑利钠肽前体(NT-pro BNP)表达水平的影响。方法采用随机数字法,将122例ACS患者分为观察组(瑞舒伐他汀钙)及对照组(阿伐他汀钙),每组61例。比较治疗4、8、16周时两组患者血脂水平及NT-pro BNP、超敏C反应蛋白(Hs-CRP)表达水平差异,并对两组治疗效果及并发症发生情况进行比较。结果治疗16周时,观察组患者三酰甘油、低密度脂蛋白胆固醇、总胆固醇水平低于对照组,且高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.05);同时,治疗周期内,两组患者不同治疗时期下NT-pro BNP、Hs-CRP表达水平差异有统计学意义(P<0.05),且观察指标均与时间存在交互作用(FNT-pro BNP=5.71,FHs-CRP=5.34);观察组患者治疗总有效率为86.88%,显著高于对照组(P<0.05),但两组患者不良反应发生率差异无统计学意义(P>0.05)。结论瑞舒伐他汀钙能有效改善ACS患者机体血脂水平,降低NT-pro BNP及Hs-CRP表达水平,提高总体治疗效果,具有较高的临床应用价值。

Objective To investigate the impact of rosuvastatin calcium in patients with coronary sclerosis and plasma NT-proBNP level of expression of acute coronary syndrome. Methods A total of 122 cases of acute coronary syndrome patients diagnosed were random-ized into the study group(rosuvastatin calcium)and control group(atorvastatin calcium),with 61 cases in each group. Two groups of pa-tients were compared in terms of lipid levels and NT-proBNP,Hs-CRP expression level in 4,8 and 16 weeks time,and the effects of treat-ment,and complications were compared as well. Results In 16 weeks of treatment,LDL-C,level of TC level decrease were lower,and HDL-C level was higher in TG observation group compared with those of the control group,and the difference was statistically significant (P < 0. 05);at the same time,within the treatment period,the difference in NT-proBNP,Hs-CRP expression levels in two groups of patients with different treatment period was statistically significant(P < 0. 05),and the observed indicators were interacted with time(FNT-proBNP =5. 71,FHs-CRP = 5. 34). In addition,the observation groupˊs total effective rate was 86. 88% ,significantly higher than that of the control group (P < 0. 05),but there was no significant difference between the two groups with respect to the incidence of adverse reactions(P > 0. 05). Conclusion Rosuvastatin calcium can improve the body blood lipid levels,lower NT-proBNP and Hs-CRP expression levels and improve o-verall treatment effect,with a high clinical value.