PI3K蛋白在食管鳞癌中的表达与临床意义

Expression and clinical significance of PI3K proteins in esophageal squamous cell carcinoma

目的检测PI3K在食管鳞癌及正常食管中的表达情况,探讨其临床意义。方法采用免疫组化的方法检测56例食管癌组织及20例正常食管组织中PI3K基因的表达,分析肿瘤组织中的PI3K表达与临床病理特征的关系。结果 PI3K蛋白在食管鳞癌组织中的阳性表达率为78.6%(44/56),在正常食管组织的阳性表达率为15.0%(3/20),差异有统计学意义(P<0.05)。结论 PI3K表达与食管癌发生发展及侵袭转移有关,可作为评价食管鳞癌生物学行为的指标。

Objective To detectthe PI3 K expression in the esophageal squamous cell carcinoma and the normal esophageal tissues,and to explore its clinical significance. Methods Using immunohistochemical methods,the PI3 K gene expression in 56 cases of tumor tissues and 20 cases of normal esophageal tissues were detected,together with association analysis of tumor tissue PI3 K expression with clinical pathological characteristics. Results The positive expression rate of PI3 K protein in the esophageal squamous cell carcinoma was 78. 6%( 44/56),while the positive rate was 15. 0%( 3/20) in the normal esophageal tissues,and their difference was statistically significant( P < 0. 05). Conclusion The PI3 K over-expression play san important role in the carcinogenesis,progression,invasion and metastasis of esophageal carcinoma,and could be used as a valuable biomarker to evaluate biological characteristics of esophageal carcinoma.