常染色体显性遗传性多囊肾病合并感染患者临床特点及病原菌分析

Clinical and Pathogen analysis of autosomal dominant polycystic kidney disease patients with infection

目的探讨常染色体显性遗传性多囊肾病(ADPKD)合并感染患者的临床特点、病原菌分布及耐药情况。方法回顾性分析安徽医科大学附属省立医院2008年1月至2015年12月收治103例ADPKD合并感染患者的临床资料。结果 103例ADPKD合并感染患者中,尿路感染占69.90%,其次为支气管肺炎、胆道感染。尿路感染病原菌以革兰氏阴性菌居多(73.53%),其中大肠埃希菌最为多见(41.18%)。大肠埃希氏菌对药物的耐药性明显。结论 ADPKD合并感染以尿路感染最为常见,病原菌主要为革兰氏阴性菌。确诊后应及时予以抗感染治疗,并根据病原学检查及药物敏感试验结果调整抗菌药物。

Objective To investigate the clinical characteristics,pathogenic bacteria distribution and drug resistance of patients with autosomal dominant polycystic kidney disease( ADPKD). Methods The clinical data of 103 patients with ADPKD complicated with infection were analyzed. Results Urinary tract infection was the main infection in ADPKD patients( accounting for 69. 90% of the total number of infected patients),and the second was bronchial pneumonia. Urinary tract infections caused by Gram negative bacteria mostly( 73. 53%),in which Escherichia coli is the most common( 41. 18%). The drug resistance of Escherichia coli is particularly significant. Conclusion Urinary tract infection is the most common of patients with ADPKD complicated with infection. After diagnosis,the anti infection treatment should be given in time,and the effective antimicrobial agents should be adjusted according to the pathogenic examination and drug sensitivity test results.