奶牛乳房炎抗生素防治失败原因探讨

THE REVIEW OF THE REASONS FOR FAILURE OF ANTIBIOTIC THERAPY FOR BOVINE MASTITIS

奶牛乳房炎主要由病原微生物引起,抗生素的应用在奶牛乳房炎控制中起了重要作用。本文着重从病原微生物—宿主—抗生素三个方面及相互作用关系中论述了奶牛乳房炎抗生素治疗失败的机制,包括:抗生素的选择、吸收、分布及抗生素的细胞内分布;细菌的被动选择、耐药性和细胞内寄生;细菌对吞噬细胞功能的影响,抗生素对吞噬细胞功能的影响及乳腺的重新感染。

Mastitis in the inflammation of bovine mammary gland which is mostly caused by pathogenic microor-gan isms.Antibi otics therapy plays and important role in the control of bovine mastitis.This article intends to re-view as follows :Role of Pathogens,Host and antibiotics vis-a-vis their interaction in mastitis treatment including antibiotic selection、absorption、tissue and intra cellular distribution;an tibiotic bacterial selection、bactte rial resis tance to antibi otics、intracellular parasite and its effects on the phagocytic function;effects of antibiotics on phagocyte and over all failure of the antibiotic treatment in the control of bovine mastitis.