摘要
Background:Several studies suggested that hypertension is positively related to cancer incidence and mortality.In this study,we investigated the association between perioperative blood pressure(BP) and long?term survival out?comes in patients with rectal cancer.Methods:This study included a cohort of 358 patients with stages I–III rectal cancer who underwent a curative resection between June 2007 and June 2011.Both pre? and postoperative BPs were measured,by which patients were grouped(low BP:<120/80 mm Hg;high BP:ints were di≥120/80 mm Hg).The survival outcomes were compared between these two groups.The primary endposease?free survival(DFS) and cancer?specific survival(CSS).Results:Univariate analysis showed that patients with high preoperative systolic BP had lower 3?year DFS(67.2% vs.82.1%,P = 0.041) and CSS rates(81.9% vs.94.8%,P = 0.003) than patients with low preoperative systolic BP,and the associations remained significant in the Cox multivariate analysis,with the adjusted hazard ratios equal to 1.97 [95% confidence interval(CI) = 1.08–3.60,P = 0.028] and 2.85(95% CI = 1.00–8.25,P = 0.050),respectively.Similarly,in postoperative evaluation,patients with high systolic BP had significantly lower 3?year CSS rates than those with low systolic BP(78.3% vs.88.9%,P = 0.032) in univariate analysis.Moreover,high pre? and/or postoperative systolic BP presented as risk factors for CSS in the subgroups of patients who did not have a history of hypertension,with and/or without perioperative administration of antihypertensive drugs.Conclusions:High preoperative systolic BP was an independent risk factor for both CSS and DFS rates,and high postoperative systolic BP was significantly associated with a low CSS rate in rectal cancer patients.Additionally,our results suggest that rectal cancer patients may get survival benefit from BP control in perioperative care.However,further studies should be conducted to determine the association between BP and CSS and targets of BP control.
Background:Several studies suggested that hypertension is positively related to cancer incidence and mortality.In this study,we investigated the association between perioperative blood pressure(BP) and long?term survival out?comes in patients with rectal cancer.Methods:This study included a cohort of 358 patients with stages I–III rectal cancer who underwent a curative resection between June 2007 and June 2011.Both pre? and postoperative BPs were measured,by which patients were grouped(low BP:<120/80 mm Hg;high BP:ints were di≥120/80 mm Hg).The survival outcomes were compared between these two groups.The primary endposease?free survival(DFS) and cancer?specific survival(CSS).Results:Univariate analysis showed that patients with high preoperative systolic BP had lower 3?year DFS(67.2% vs.82.1%,P = 0.041) and CSS rates(81.9% vs.94.8%,P = 0.003) than patients with low preoperative systolic BP,and the associations remained significant in the Cox multivariate analysis,with the adjusted hazard ratios equal to 1.97 [95% confidence interval(CI) = 1.08–3.60,P = 0.028] and 2.85(95% CI = 1.00–8.25,P = 0.050),respectively.Similarly,in postoperative evaluation,patients with high systolic BP had significantly lower 3?year CSS rates than those with low systolic BP(78.3% vs.88.9%,P = 0.032) in univariate analysis.Moreover,high pre? and/or postoperative systolic BP presented as risk factors for CSS in the subgroups of patients who did not have a history of hypertension,with and/or without perioperative administration of antihypertensive drugs.Conclusions:High preoperative systolic BP was an independent risk factor for both CSS and DFS rates,and high postoperative systolic BP was significantly associated with a low CSS rate in rectal cancer patients.Additionally,our results suggest that rectal cancer patients may get survival benefit from BP control in perioperative care.However,further studies should be conducted to determine the association between BP and CSS and targets of BP control.
基金
provided by the National Basic Research Program of China (973 Program) (No.2015CB554001,JW )
the National Natural Science Foundation of China (No.81472257,YL
No.81201920,YL
No.81502022,XW )
the Natural Science Foundation of Guangdong Province (No.S2013010013607,YL)
the Science and Technology Program of Guangzhou (No.201506010099,YL)
the Fundamental Research Funds for the Central Universities (Sun Yat-sen University) (No.2015ykzd10,YL
No.13ykpy37,YL)
Wu Jieping Medical Foundation (320675015173 HY)
