摘要
目的：研究浅蓝霉素能否抑制大肠癌细胞的生长及其可能作用机制。方法：应用四甲基偶氮唑蓝（MTT）方法观察浅蓝霉素对大肠癌细胞的影响。以流式细胞仪对浅蓝霉素作用后肿瘤细胞的细胞周期变化进行观察。结果：浅蓝霉素对大肠癌细胞生长的抑制作用具有时间－剂量依赖关系，与对照组比较有显著性差异（P＜0．05）。浅蓝霉素引起大肠癌细胞发生G2／M期阻滞。结论：浅蓝霉素通过诱导肿瘤细胞发生G2／M期阻滞而引起大肠癌细胞死亡。
同被引文献6
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