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Quantification of atorvastatin in human plasma by liquid chromatography tandem mass spectrometry and its application for bioequivalence study of three formulations

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摘要 Atorvastatin, a chemical ([R-(R*, R*)]-2-(4-fluorophenyl)-b,ddihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]1 H-pyrole-1-heptanoic acid), is a synthetic HMG-Co A (3-hydroxy-3-methylglutaryl-coenzyme A)reductase inhibitor. It has been shown to be remarkably efficacious in decreasing the level of cholesterol and triglyceride(1)In order to quantify the level of atorvastatin in plasma, it needs a sensitive, rapid and selective method.
出处 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2016年第1期66-67,共2页 亚洲药物制剂科学(英文)
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