Pharmacokinetic interaction between irbesartan and Orthosiphon stamineus extract in rat plasma

Orthosiphonstamineus commonly known as kumis kucing has been used traditionally for rheumatoid,gout,renal calculus,hypertension,diabetes,etc.[1].It is often used in combination with synthetic hypertensive drugs like irbesartan.However,both effectiveness combination herbal medicine with modern pharmaceuticals,and the possible adverse effects from herb–drug interactions remain to be verified.