摘要
Sildenafil citrate is a highly selective phosphodiesterase-5(PDE-5)inhibitor.It is used for treatment of erectile dysfunction and pulmonary hypertension[1].Sildenafil citrate is categorized in BCS class 2 so it is developed as a citrate salt to increase water solubility(4.1 mg/mL)[2].The conventional product has been developed as a tablet dosage form.It is rapidly absorbed after oral administration,but gives a relatively low oral bioavailability of about 40%and late onset of action[2].Dry foam formulation technology is an alternative approach to overcome such a problem.
