谷氨酰胺在脓毒症患者营养支持中的作用

Effects of Glutamine on Nutrition Support of Patients with Sepsis

将32例脓毒症患者随机分为治疗组及对照组,每组16例。对照组给予基础营养支持,治疗组在基础营养支持上加用谷氨酰胺,对两组患者全身炎症反应的指标改善程度及肠道功能进行对照比较。结果显示,治疗组炎症指标改善程度优于对照组;治疗组腹泻发生率(25%)低于对照组(37.5%);治疗组肠道真菌感染发生率(18.75%)低于对照组(25%)。表明谷氨酰胺能改善脓毒症患者肠道功能、维护肠粘膜屏障、提高免疫机能、减少并发症的发生、改善预后。

32cases of sepsis patients were randomly divided into treatment group and control group.Based on nutritional support,the control group(16cases)was given compound amino acid,and the treatment group(16cases)used compound amino acid combined with glutamine.The indexes of systemic inflammatory response and bowel function were compared between the two groups.Results showed that in treatment group,improving indexes were better than the control group;the incidence of diarrhea in treatment group(25%)in was lower than control group(37.5%);the intestinal fungal infection in treatment group(18.75%)was lower than control group(25%).In sepsis patients,glutamine could improve intestinal function,maintain the intestinal mucosal barrier,improve immune function,reduce complications and improve the prognosis.