摘要
白花蛇舌草Hedyotisdiffusa是一种传统的抗肿瘤中药 ,可广泛应用于治疗各种肿瘤 ,从白花蛇舌草中提取出水溶性提取物 (H1 和H2 ) ,采用接种S 180的荷瘤小鼠灌服其 10天 ,观察H1 和H2 的抗肿瘤活性。H1 (12 5 ,6 2 5mg·kg- 1 )和H2(6 2 5 ,31 2 5mg·kg- 1 )能显著抑制小鼠移植性S 180实体瘤的生长 ,而且H1 和H2 与环磷酰胺合用 ,可以明显改善环磷酰胺所致的免疫器官萎缩和造血系统的损伤。
Bai-Hua-She-She-Cao Hedyotis diffusa Willd. (Ru-biaceae) is a medicinal herbwidely distributed in northeast Asian countries. In traditional Chinese medicine, it has the effectof 'clearing away heat and toxic material, promoting blood circulation and removing blood stasis'.It is a well known Chinese folk-medicine used for the treatment of appendicitis, sore throat, mumps,acne, sebo-rheic dermatitis and various kinds of tumors, such as tumors of digestive tract,carcinoma of liver. It was reported that the MeOH extract of H. diffusa demonstrated a significantantitumor activity and ursolic acid succeeded in being isolated from the MeOH extract as an activecomponent . Shan BN, et al suggested that the direct aqueous extract of H. diffusa hadimmuno-modulating activity and antitumor activity in vitro through stimulating the immune system tokill or engulf tumor cells. But regarding anti-tumor activity in vivo of water soluble extracts fromH. diffusa, no detail was reported. Therefore, we prepared water soluble extracts (H_1 and H_2)from H. diffusa and evaluated their anti-tumor property in vivo experiments as well as protectiveeffect on chemo-therapeutic damage.
基金
ThisresearchissupportedbyJiangsuAdministrationofTraditionalChineseMedicine
