透明质酸酶制剂治疗外周输液渗漏研究

The study on the treatment of swelling and scleroma Resulted from leakage of infusion

目的探讨透明质酸酶制剂治疗外周输液渗漏的疗效。方法分动物实验及临床实验 ,临床随机选择住院病人中因静脉注射发生药物外渗的病人 ,分为两组 ,对照组 2 3例用 10 %硫酸镁湿敷 ,观察组用透明质酸酶乳膏剂涂擦。结果透明质酸酶制剂对注射外渗所致的肿胀具有较好的治疗作用 ,消肿时间明显少于临床常用的硫酸镁湿敷法 ,P <0 .0 1差异有显著意义。结论透明质酸酶制剂治疗药物静脉外渗所致肿胀具有良好效果 ,明显优于临床常用的 10 %硫酸镁湿敷法 ,可广泛应用于临床。

Objective To study the effectiveness of hyaluronidase pharmaceutics in treating of peripheral infusion leakage. Method Animal and clinical were conducted, hospitalized patients with infusion leakage were randomly selected and divided into control and experimental groups in clinical test, in control group, 23 cases patients were given 10% bitter salt as wet packing, hyaluronidase pharmaceutics liniment was given in experimental group. Result The hyaluronidase pharmaceutics is effective in treating the swelling resulting from infusion leakage, the timing for reduce swelling is significantly less than that of bitter salt wet packing ( P<0.01). Conclusion hyaluronidase pharmaceutics is effective in treating thew swelling resulting vein infusion leakage and excelled the clinically common used 10% bitter salt wet packing, it's could be widely used in clinical practice.