国产甲壳胺流变学性质及其影响因素的研究

Studies on Rheological Properties of Chitosan

用旋转粘度计测定甲壳胺的流变学性质 ,并考察了不同脱乙酰度、浓度、溶液 p H值、离子强度、胃蛋白酶、温度以及不同性质的药物等因素对甲壳胺流变学性质的影响。结果表明 ,甲壳胺溶胶属假塑型流体且无触变性 ,上述因素对甲壳胺的流变学性质均有影响。其中甲壳胺浓度对其流变学性质影响最大 。

The rheological properties of chitosan and the factors such as degree of deacetylation, concentrations, pH, electrolyte, pepsin, temperature and different properties of drug were investigated. The results showed that chitosan exhibited pseudoplastic construction and non thixotropy appeared in the solutions, and its concentration had most obvious effect on the rheological properties.