四联疗法治疗类风湿性关节炎53例

53 CASES OF RHEUMATOID ARTHRITIS TREATED WITH QUARTET THERAPY

目的 :观察四联疗法对活动期类风湿性关节炎 (RA)的疗效。方法 :将 91例活动期RA患者随机分为治疗组 (5 3例 )和对照组 (38例 )。治疗组用四联疗法 (雷公藤多苷片、奈普生胶囊或布洛芬片、中药痛痹汤以及药浴 ) ;对照组用二联疗法 (雷公藤多苷片、奈普生胶囊或布洛芬片 )。观察患者的临床症状、体征、体液免疫和氧自由基代谢水平的变化情况。结果 :四联疗法能抑制异常亢进的体液免疫和氧自由基反应 ,改善微循环 ,改善临床症状、体征 ,缓解病情 ,疗效优于二联疗法 ,表现在 :①开始起效时间快 ;②改善症状、体征作用强 ;③显效率和总有效率更高 ;④消化道不良反应发生率低。结论

Objective:To observe the therapeutic effect of Quartet Therapy on rheumatoid arthritis(RA) in active stage.Method:91 patients of RA in active stage were randomly divided into two groups.The treatment group(53 cases) were treated with quartet therapy(multi glycoside tablet of Tripterygiun Wilfordii,naproxen capsule or ibuprofen tablet,Tongbi decoction and medicated bathing).The control group(38 cases) were treated with duet therapy(multi glycoside tablet of Tripterygiun Wilfordii,naproxen capsule or ibuprofen tablet).The changes of clinical symptoms,signs,the levels of humoral immunity and oxygen free radical were observed.Result:The quartet therapy could arrest the abnormally hyperfunctioned humoral immunity and reaction of oxygen free radical,improve the microcirculation,thus ensuring the improvement of the clinical symptoms and signs and remission of the condition.The quartet therapy ,in comparison with the duet one,had a less effect and better curative property marked by quick response to the drugs,strong action in improving symptoms and physical signs,high marked and total effective rate amd low incidence of the side effect of the digestive tract.Conclusion:The quartet therapy has a promising therapeutic effect on RA in active stage.