6[3]Fox RI. Mechanism of action of leflunomide in RA[J].J Rheum .1998,25(Suppl 53)∶S27-S32．
7[4]Smolen JS,Kalden JR,Scott DL，et al.Efficacy and safety of le flunomid e compared with placebo and sulphasalazine in active RA:a double-blind, randomi zed,multicenter trial[J].Lancet,1999,353,9149∶259-266．
8[5]Rozman B.Clinical experience with leflunomide in RA[J].J Rheu m，1998,25 (Suppl 53)∶S20-S26．
9[6]Weaver A,Caldwell J,Olsen N,et al.Treatment of active RA with lefluno mide compared to placebo or MTX[C].Poster at 62nd ACR in San Diego, 1998.
10[7]Moldovan F,Pelletier JP,Jolicoeur FC,et al.Diacerhein and rhe in redu ce the ICE induced IL-1β and IL-18 activation in human osteoarthritic cartila ge[J].Osteoarthritis and Cartilage，2000,8(3)∶186-196.
