原发肾病综合征并发医院感染的危险因素分析

Analysis of risk factors for complication with hospital infection in patients with primary nephrotic syndrome

目的 探讨原发肾病综合征患者并发医院感染的易感因素与防治措施。方法 采用回顾性调查法分析 14 6例原发肾病综合征患者的有关临床资料。结果 原发肾病综合征患者医院感染率达35 6 % ;感染部位以呼吸道为主 (46 4 % ) ,泌尿道次之 (17 9% ) ;感染率高低与住院天数 (P <0 0 1)、激素及免疫抑制剂联合应用、血清IgG水平低下有关 ;感染病原菌以革兰氏阴性杆菌为主 ,真菌已成为其重要病原菌。结论 住院天数长、激素与免疫抑制剂的应用及血清IgG水平低下是造成医院感染的危险因素 ,对该类患者应相应加强防护。

Objective To find out about the risk factors and prevention and treatment measures for complication with hospital infection in patients with primary nephrotic syndrome. Methods An analysis was conducted by means of retrogressive survey of the relevant clinical data on 146 cases of patients with primary nephrotic syndrome. Results The rate of hospital infection in patients with primary nephrotic syndrome reached 35 6%, with the respiratory tract being the main infected site(46 4%) and the urinary tract being the next major infected site(17 9%); the rate of infection is related to such factors as length of stay(P<0 01), the use of hormones together with immunosuppressants, and low level of serum IgG; the main infection causing pathogenic bacterium is gram negative bacterium, and fungus has become a key pathogenic bacterium. Conclusion Great length of stay, combined use of hormones and immunosuppressants and low level of serum IgG are the major risk factors for complication with hospital infection in patients with primary nephrotic syndrome, and measures need to be taken to protect them against these risk factors.