静脉用氯化钠注射液中微粒的考察

A Survey of Microparticulate Matters in Sodium Chloride Solutions for Intravenous Administration

目的 :考察不同装量的静脉用氯化钠注射液中不溶性微粒的变化 ,保障临床用药安全。方法 :用注射液微粒分析仪分别检查不同装量的氯化钠注射液中的不溶性微粒。结果 :经反复抽取过的大体积包装的注射液的剩余液体中不溶性微粒有 5 0 %超出了控制标准。结论 :在溶解干粉针剂或稀释针剂作静脉注射时 ,应使用小装量的氯化钠注射液。

Objective:To survey the situation of micro particulate matters in bottled sodium chloride solutions of different volumes for intravenous administration in the hope of ensuring safety in the clinical application of the solutions. Method:Insoluble microparticulate matters in sodium chloride solutions of different volumes were separately examined with a specialized electronic particle counter. Results:The number of microparticulate matters in small volume (10 mL/ampul) 0.9% sodium chloride solutions did not exceed the control standard. However, the number of microparticulate matters in more than 50% of the remnants of large volume (500 mL/bottle) 0.9% sodium chloride solutions, the bulk of which had been used up by repeated aspiration for dissolving powdered remedies, exceeded the control standard. Conclusion:Small volume sodium chloride solutions should be used for dissolving powdered remedies or diluting concentrated injections for intravenous administration.