补肾壮骨胶囊对氢化可的松引起骨质疏松症雄性大鼠生化指标的影响

Effects of Bushenzhuanggu capsule on biochemical markers in hydrocortisoneinduced osteoporotic male rats

目的:了解补肾壮骨胶囊对氢化可的松引起骨质疏松症雄性大鼠生化指标的影响。方法:采用临床检验方法测定补肾壮骨胶囊对氢化可的松引起骨质疏松症雄性大鼠血清钙、磷、血清碱性磷酸酶的影响。结果:与空白对照组相比,模型对照组的血钙、血磷显著下降,碱性磷酸酶升高。与模型对照组相比,补肾壮骨胶囊高、低剂量组血钙、血磷显著升高,碱性磷酸酶下降。结论:补肾壮骨胶囊对氢化可的松引起雄性大鼠骨质疏松症有明显的防治作用。

OBJECTIVE:To study effects of Bushenzhuanggu capsule on biochemical markers in hydrocortisone-induced osteoporotic rat models. METHODS: The blood concentrations of calcium, phosphorus and ALP of hydrocortisone-induced osteoporotic rats were determined by clinical biochemical assay. RESULTS: After treatment with Bushenzhuanggu capsule, the blood concentrations of calcium, phosphorus and ALP of hydrocortisone-induced osteoporotic rats were increased, the activity of ALP was decreased. CONCLUSION: Bushenzhuanggu capsule has some therapeutic effects on hydrocortisone-induced osteoporotic rat models.