复方替硝唑栓剂的体外抗菌活性研究

Study on Antibacterial Activity in Vitro of Compound Tinidazole Suppository

目的 测定复方替硝唑栓剂的体外抗菌活性及临床意义。方法 采用试管液体二倍稀释法测定复方替硝唑栓剂的体外最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。结果 复方替硝唑栓剂对革兰氏阳性菌、阴性菌、厌氧菌均显示很强的抗菌活性,其MBC分别为0.15～0.32mg/L、0.10～0.39mg/L和0.05～0.29mg/L,并与复方甲硝唑栓剂相比差异有显著性意义(P<0.05)。结论 复方替硝唑栓剂治疗妇科炎症具有临床意义。

Objective Determine antibacterial activity and the clinical significance in vitro of compound tinidazole suppository. Methods Adopt tube liquid twice times dilute determine MIC and MBC of compound tinidazole suppository. Results Compound tinidazole suppository is strong activity to G+ , G- and anaerobic bacteria. Conclusions Compound tinidazole suppository is clinical significance for gynaecopathia.