冠心病患者可溶性细胞粘附分子的检测及其临床意义

Serum soluble cell adhesion molecules in patients with coronary heart disease

目的 :检测冠心病 (CHD)患者可溶性细胞间粘附分子 1(sICAM 1)及P 选择素的变化 ,探讨其在CHD发病机制中的意义。方法 :用ELISA法和酶法分别检测 6 8例CHD患者和 5 5例对照者的血清sICAM 1、P 选择素、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯 (TG)、总胆固醇水平 ,Gensini积分法评价冠状动脉病变程度 ,进行统计学分析。结果 :CHD患者血清sICAM 1和P 选择素水平均较对照组高 ,且差异有非常显著性意义 (均P <0 .0 0 1) ;sICAM 1水平与冠状动脉病变程度显著相关 (r =0 .6 6 2 ,P <0 .0 0 1) ;TG与sICAM 1水平呈正相关 (r =0 .4 0 3,P <0 .0 1) ;P 选择素与冠状动脉病变程度无明显关系。结论 :sICAM 1及P 选择素可能参与了CHD的发病过程 ,血清sICAM 1的检测有助于临床病情分析 ,TG是影响sICAM 1水平的因素之一。

Objective:To explore the significance of cellular adhesion molecules (CAMs) in coronary heart disease (CHD) by measuring serum soluble intercellular adhesion molecule 1 (sICAM 1) and P selectin (Ps) levels in patients with CHD. Method:By means of enzyme linked immunosorbent assay (ELISA), the concentrations of serum sICAM 1 and Ps were measured in 68 patients with CHD as well as in 55 controls. The Gensini scoring system was used to determine the severity of coronary artery lesions. Result:The concentrations of sICAM 1 and Ps were significantly higher in CHD patients than those in controls (both P< 0.001 ). A significant correlation between the severity of the coronary artery lesions and the levels of serum sICAM 1 and total cholesterol (TC) was found from the multiple regression analysis (P< 0.001 and P< 0.01 ). The concentration of triglyceride (TG) might influence the level of serum sICAM 1. Conclusion:ICAM 1 and Ps may involve in the pathogenesis of coronary heart disease. Serum sICAM 1 may be an available index for the severity of CHD.