镉接触工人体内血清性激素水平的变化

Changes of serum sex hormone levels in male workers exposed to cadmium

目的 探讨镉接触工人体内血清性激素水平的变化及其机制。方法 选取南方某冶炼厂镉接触工人及当地健康男性为调查对象 ,经空气采样测定各车间空气中镉的浓度 ,用原子吸收分光光度法测定尿镉 ,并经肌酐校正作为调查对象体内镉负荷的生物标记物 ;同时测定工人体内性激素水平 ,并进行镉接触的剂量 效应评定。结果 在控制年龄等混杂因素后 ,血清睾酮水平随镉接触水平的增高而呈升高趋势 ,其中尿镉为 1 0 9～ 2 1 9μmol/mol肌酐及 >2 1 9μmol/mol肌酐组的睾酮水平分别为 :1 3 0 0nmol/L和 1 1 37nmol/L ,与 0 0～ 2 2 μmol/mol肌酐组的 9 31nmol/L比较 ,差异有显著性 ;电解车间及尿镉 >2 1 9μmol/mol肌酐组工人的血清黄体生成素水平分别为 4 1 1U/L和 4 32U/L ,显著高于对照组的 2 52U/L和尿镉 0 0～ 2 2 μmol/mol肌酐组的 2 64U/L。

Objective To investigate the changes in serum levels of sex hormones in male workers occupationally exposed to cadmium (Cd) Methods Eighty five Cd exposed workers in a cadmium refinery in the south China and 76 local healthy subjects as control were selected in the study Air samples in the workplaces were collected and detected for Cd concentration Urinary Cd (UCd) level of the workers was measured by graphite atomic absorption spectrometry (AAS) and adjusted by urine level of creatinine (Cr), as an indicator of Cd burden in the body of all subjects. Also, their serum levels of testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were determined with radioimmunoassay and enzymeimmunoassay, respectively, and dose effect relationship was evaluated Results The serum testosterone levels in Cd exposure group with 10 9-21 9 and >21 9 μmol/mol Cr were 13 00 and 11 37 nmol/L, significantly higher than that (9 31 nmol/L) in those with 0 0-2 2 μmol/mol Cr Significantly more increased level of LH (4 11 and 4 32 U/L) was detected in heavy exposure group in the workshop for electrolysis than in control group (2 52 U/L) and in the group with 0 0-2 2 μmol/mol Cr of UCd (2 64 U/L) No changes in serum level of FSH were found related to Cd exposure Conclusion Occupational Cd exposure could independently contribute to the changes of serum levels of sex hormone in male workers