摘要
采用李氏精神康复胶囊治疗精神分裂症患者204例,并与传统抗精神病药物氯丙嗪治疗的40例作对照。结果表明,两组疗效相当,无显著性差异(P>0.05)。BPRS因子分析,对迟滞、活动过多、敌对猜疑较其它因子明显。CGI疗效指数(EI)两组之间比较,有极显著性差异(P<0.01)。副作用中药组极少见,有极显著性差异(P<0.01)。动物实验表明,李氏精神康复胶囊具有镇静(抑制小鼠自发活动)、催眠(延长戊巴比妥纳阈剂量小鼠睡眠时间和戊巴比妥钠阈下剂量小鼠入睡个数)作用。对阿朴吗啡诱发的小鼠定向抬头活动和攀爬行为有明显的抑制作用。
Two hundred and four schizophrenics were treated using li's mental rehabilitation capsule,and compared with 40 patients who took classical antipsychotic chlorpramazine. Result showed that the curative effect of the 2group was equivalent and had no significant difference (P >0. 05). According to BPRS factor analysis,the retardation,activation and hostile suspiciousness was more obvious than other factors. There was extremely significant difference in the EI of EGI curative effect (P<0. 01),the side effect of the Chinese drug's group were fewer and had extremely significant difference (P<0. 01 ).Animal experiment showed that the li's capsule had sedation (inhibiting spontaneous activity) and hypnotism (prolonging small mouse's sleep time and numbers when the threshold orsubthreshold dosage of pantance) ,and had obvious inhiliting action on the behaviors of raising his head and climbing of small mouse.
