老年2型糖尿病合并无症状性心肌缺血患者自主神经功能的变化

The Chang of Automotic Function In Old Type2 Diabetic Patients With Silent Myocardial Ischemia

目的 无症状性心肌缺血在 2型糖尿病患者中是常见的合并症 ,本研究旨在探讨 2型糖尿病合并无症状性心肌缺血时自主神经功能的变化。方法 4 8例 2型糖尿病患者和 32例非糖尿病患者进行 2 4小时动态心电图监测 ,所有患者监测时间均大于 2 3小时 ,并测定心率变异性的时域分析指标 SDNN、SDANN、r MSSD、p NN50 。结果 2型糖尿病合并无症状性心肌缺血时心率变异性指标较对照组明显降低 ,P值分别小于 0 .0 0 1、 0 .0 0 1、 0 .0 0 1和 0 .0 5有显著的差异性 ,而 2型糖尿病无心脏病变组仅 SDNN、 SDANN有较明显的降低 ,P值分别小于 0 .0 0 1和 0 .0 1。结论

Objectives Silent myocardial ischemia is common in old patients with type 2 diabetes This study designed to assess the role of autonomic function in old type 2 diabetic patients with silent myocardial ischemia Methods 48 diabetic and 32 nondiabetic patients underwent 24 h ambulatory ECG(Holter)monitoring for measurement of heart rate variability Results Diabetic and nondiabetic patients were similar in age,sex and left ventricular ejection fraction However,autonomic function was impaired in the type 2 diabetic patients with silent myocardial ischemia group Conclusions\ Abnormalities of autonomic function in the type 2 diabetic patients with silent myocardial ischemia group is quite clearer than in the diabetic patients without silent group and the contrast group