1Li J, Yen C, Liaw D, et al. PTEN, a putative protein ryrosinephosphatase gene mutated in human brain, breast and prostate cancer. Science, 1997, 275 (5308): 1876-1879, 1943-1947.
2Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumor suppressor gene, MMACl, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet, 1997, 15(4): 356～362.
3Li DM, Sun H. TEPl, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res, 1997, 57 (11): 2124～2130.
4Tamura M, Gu J, Matsumoto K, et al. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science, 1998, 280 (5369): 1614～1617.
5Myers MP, Pass I, Batty IH, et al. The liqid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl AcadSciUSA, 1998, 95 (23): 13513～13518.
6Gu J, Tamura M, Yamada KM. Tumor suppressor PTEN inhibits integrinand growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol, 1998, 143 (5): 1375 ～1383.
7Wang SI, Puc J, Li J, et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res, 1997, 57 (19): 4183-4186.
8Cairns P,Okmi K,Halachmis S,et al. Frequent inactivtion of PTEN/ MMAC1 in primary prostate cancer. Cancer Res, 1997,57 (22): 4997 ～ 5000.
9Risnger JI, Hayes AK, Berchuck A, et al. PTEN/MMACl mutations in endometrial cancers. Cancer Res, 1997, 57 (21): 4736-4738.
10Okami K, Wu L, Riggins G, et al. Analysis of PTEN/MMACl alterations in aerodigestive tract tumors. Cancer Res, 1998, 58 (3): 509～511.
