摘要
大部分化学致癌物进入体内,或经代谢活化后,可与生物大分子———蛋白质或核酸形成共价相连的加合物,DNA加合物的形成是化学致癌过程中一个早期、可检测到的关键步骤。加速器质谱技术(acceleratmassspectrometry,AMS)的DNA加合物检测,是目前最灵敏的检测方法,提供了人们研究低剂量效应的直接有力的手段。
Most chemical carcinogens,after intake,or after metabolic activation,can form covalent modifications of DNA (DNA adducts).DNA adducts formation induced by carcinogenic chemicals reflects exposure and is directly related to tumor formation.DNA adduct is a valid indicator of early key stage of carcinogenesis.Accelarator mass spectrometry(AMS)is a relatively new nuclear technique,has been developed for the detection of DNA adduct with great detection sensitivity.This powerful application allows studying molecular effects at the low-dose carcinogen exposure.
出处
《国外医学（放射医学核医学分册）》
2002年第3期124-126,共3页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金
国家自然科学基金资助项目(19875077)
