急性时相蛋白的联合检测对甲型副伤寒的临床辅助诊断价值

Significant of the phasic protein detection in supporting the clinical diagnosis of Salmonella paratyphi A

目的 对甲型副伤寒患者血清时相蛋白进行动态检测 ,找出较敏感的炎症标记蛋白。方法 采用散射速率比浊法对 32 5例甲型副伤寒和 30 0例非感染患者的 8项时相蛋白作动态检测。结果 感染早期CRP及感染极期AAG水平与正常参考值相比明显升高 ,并随着感染的控制呈逐渐下降趋势 ,有 31例复发病例也呈升高趋势 ;TRF及PAB水平与正常参考值相比明显下降 ,随着疾病的变化逐渐恢复正常。其余 4项急性时相蛋白升高的只占32 5例感染患者的 8%。非感染组 8项时相蛋白均在正常范围内。结论 CRP、AAG为感染甲型副伤寒时敏感的急性时相蛋白 ,TRF。

Objective To identify some sensitive inflammatory markers from the Salmonella paratyphi A infected patient serum. Methods Scatter radiation assay was used to detected 8 phasic proteins in 325 salmonella paratyphi A patients and 300 uninfected controls. Results The markers, AAG and CRP were obviously increased in the early stage of the infected patients when compared with the normal reference value, and decreased gradually after the symptom was under control. The markers, TRF and PAB were decreased obviously when compared with reference value and gradually regained the normal level with the progress of the disease.The other acute phasic proteins increased only in 8% of 325 cases of infection. The 8 phasic proteins were all maintained in a normal range in control group. Conclusion AAG and GRP were the most sensitive up regulated acute phasic proteins while TRF PAB were sensitive down regulated phasic proteins.