核基质与细胞凋亡

Nuclear Matrix and Apoptosis

阐述了凋亡过程中 ,核基质所发生的形态、生化变化及相关凋亡基因的表达 ,尤其是凋亡早期便出现核基质蛋白的降解 .核基质是细胞核最基本的组分 ,对维持细胞核形态结构和功能非常重要 ,其主要由核纤层 ,核内骨架及核孔复合体构成 ,在DNA复制、转录、RNA加工转运等事件中起支持作用 .多少年来 ,关于凋亡时细胞核形态及生化改变的分子机理一直未阐明 ,最近对核基质与细胞凋亡的研究取得了重大进展 .

The nuclear matrix is an essential component of the nucleus which is important for the nuclear structural integrity and specific genomic functions. The nuclear matrix is composed of nuclear lamina,internal nuclear skeleton and nuclear pore complex which provides structural support for several processes such as DNA replication,transcription,and RNA splicing and transport. The molecular mechanisms about the morphological and biochemical changes which take place in the cell nucleus during the apoptotic process have escaped clarification for many years.Recently, the studies on the nuclear matrix and apoptosis have made great progress. The biochemical and morphological changes and the apoptotic genes expression detected in the nuclear matrix during the apoptotic process will be delineated. Particular emphasis will be laid on the proteolysis that some nuclear matrix proteins undergo early during the apoptotic process, which may have important biological significance in researching the molecular mechanisms of apoptosis.