新芋螺毒素SO3的合成优化与折叠关系

Optimization of synthetic and folding conditions of a novelω-conotoxin peptide SO3

用Fmoc/But方法合成了从线纹芋螺中筛选的具有镇痛作用的芋螺多肽SO3,通过对合成中偶合方法及裂解条件的优化,提高了线性肽的合成效率,减少了副产物的形成,使合成的线性肽不仅纯度好,且无需纯化即可用于下一步折叠。

A novel analgesicω-conotoxin peptide SO3from Conus striatus was synthesized with Fmoc /But method.The synthetic efficiency of linear peptide was greatly increased and the main vice-products were removed mostly through optimizing the coupling methods and cleavage conditions of Fmoc /But method.In this way the linear peptide can be used for peptide floding without further purification.