Graves病患者血清白细胞介素-6测定的临床意义

Clinical significance of detection of interleukin-6 in patients with Graves disease

目的 探讨Graves病 (GD)与免疫功能的关系。方法 采用酶联免疫吸附法 (ELISA)对 3 7例Graves病患者及3 0例正常人血清进行IL -6水平测定。结果 3 7例GD患者血清IL -6水平 (16.85± 5 .63ng/L)高于正常对照组 (9.74± 6.3 9ng/L) ,P <0 .0 0 1。IL -6水平与FT3 、TGA和MCA水平均无相关性 (r分别为 0 .0 0 4、0 .0 12、0 .0 64 ,P均 >0 .0 5 )。结论 提示在GD发病中存在IL

Objective To investigate the relationship between Graves disease and immunologic function. Methods The ELISA method was used to detect the levels of serum interleukin-6 (IL-6) in 37 patients with Graves disease (the GD group) and 30 normal individuals (the control group). Results The serum IL-6 levels in GD group were 16.85±5.63ng/L, which were higher than that in the control group, 9.74±6.39ng/L, P<0.01. The levels of IL-6 had no correlation with FT 3, TGA and MCA, the r values were 0.004, 0.012, and 0.064, respectively, all the P values were >0.05. Conclusions This suggested that IL-6 be involved in the development of Graves disease.