狼疮肾炎患者血清IL-16水平的检测及其临床意义

Clinical significance of serum and u rine IL-16level in patients with lup us nephritis.

目的:探讨狼疮肾炎患者血清白细胞介素-16(IL-16)水平变化及其临床意义。方法:狼疮肾炎患者48例,按照系统性红斑狼疮疾病活动指数(SLEDAI)分为狼疮肾炎活动组28例,狼疮肾炎静止组20例;另选非狼疮肾炎组12例,正常对照组10名,采用酶联免疫吸附法(ELISA)检测各组的血清IL-16水平。结果:狼疮肾炎活动组、静止组血清IL-16水平均较正常对照组显著增高(P<0.05),狼疮肾炎活动组血清IL-16水平与SLEDAI成显著正相关(r=0.839、P<0.01),与血清抗双链DNA抗体水平、尿蛋白及狼疮肾炎肾组织疾病活动指数呈正相关,但狼疮肾炎静止组与非狼疮肾炎组之间血清IL-16水平无统计学差异。结论:狼疮肾炎患者血清IL-16水平增高,可作为评价狼疮肾炎活动的参考指标。

Objective:To study the clinical significance o f serum and urine interleukin-16(IL-16)in patients with lupus nephritis(LN).Methods :Serum and urine IL-16was measured by Enzyme-linked immunosorbent assay(ELISA).Results:Serum and urine IL-16levels in both active and inactive LN groups were signific antly higher than that of controls(P<0.01).Serum IL-16level was correlated with systemic l upus erythematosus activity index(SLEDAI )(r=0.839,P<0.01),anti-dsDNA auto-antibody level,renal activity index and proteinuria.However,there was no difference in both serum and urine IL-16levels between inactive LN group and non-LN group.Conclusion:Serum IL-16is elevated in LN patient s and is correlated with disease acti vity.[