高血压病患者血管内皮损伤及凝血、纤溶指标变化的研究

Changes of Von-Willeband Factor,Blood Coagulation and Fibrinolysis ;Indexes in Hypertension

目的 通过观察高血压病患者血管内皮损伤和部分凝血、纤溶指标的变化 ,探讨其发生血栓栓塞性并发症的原因 ,为临床提供诊治依据。方法对Ⅰ、Ⅱ、Ⅲ级高血压病患者各 2 0例测定vonWillebrandFactor(vWF)、P -选择素、纤维蛋白原、D -二聚体 ,以健康人 2 0例为对照。结果与正常对照组比较 ,Ⅰ级高血压患者vWF、P -选择素、纤维蛋白原、D -二聚体有显著增高 (P <0 0 5 ) ;Ⅱ级和Ⅲ级高血压患者vWF、P -选择素、纤维蛋白原有非常显著性增高 (P<0 0 1) ;Ⅱ级高血压患者D -二聚体与正常对照组比较有显著增高 (P <0 0 5 ) ,Ⅲ级高血压患者D -二聚体有非常显著增高 (P <0 0 1)。结论高血压病患者存在的血管内皮损伤、血小板的激活、高纤维蛋白原血症以及纤溶方面的变化 ,可能是其并发心、脑血管疾病的原因之一。

Objective To study Von-Willeband factor,blood coagulation and fibrinolysis indexes in hypertension. Methods The plasma levels of the Von Willeband Factor(vWF), P-selectin, fibrinogen, Fibrin D-dimer were examined in hypertensive patients Ⅰ grade (n=20),Ⅱ Grade (n=20), Ⅲ Grade (n=20), with twenty healthy persons as controls. Results The concentration of vWF, P-selectin, Fibrinogen and D-dimer were higher in patients with hypertension of grade Ⅰ,Ⅱ,Ⅲ than those in controls(P<0.05). Conclusion Essential hypertensive patients had endothelium dysfunction, platelet activation, high plasma fibrinogen and impaired fibrinolysis, which may be the pathogenesis of complications such as ischemic stroke, heart attacks.