高血压患者颈动脉粥样硬化与血流动力学改变的关系研究

Hemodynamic Changes and Atherosclerosis in Carotid Artery in Hypertensives

目的 应用超声多普勒技术研究高血压症患者颈动脉血流动力学改变与粥样硬化病变之间的关系 ,评价血流动力学因素在颈动脉粥样硬化形成中的作用。方法 将 70例患者分为对照组和高血压组 ,进行颈动脉超声检查 ,按颈动脉是否存在粥样斑块将高血压组分为斑块组和无斑块组。分别计算最大剪切率 (ShearRate ,SR) ,并进行一般指标比较。结果 高血压患者颈动脉粥样斑块的发生率为 5 2 %,颈动脉内径扩大 ,峰值流速及SR均减低。斑块组患者的年龄明显高于无斑块组 ,双侧颈动脉SR均明显低于无斑块组。两组患者的血压水平、血脂及血糖水平、吸烟史、家族史、BMI均无显著性差异。结论 年龄的升高及SR减低是颈动脉粥样斑块形成的重要危险因素。

Objective To examine the relationship between hemodynamic changes and carotid artery plaque in hypertensive patients. Methods A cohort of 70 consisting subjects of normal,carotid artery plaque(CAP) and non-carotid artery plaque(non-CAP) were examined with carotid sonography. The diameters and maximal velcocity were measured, and maximal shear rate (SR) calculated. The age, blood pressure and other risk factors were evaluated. Results Patients with hypertension had larger carotid diameters, lower maximal velocity and SR than that in normal subjects. Maximal velocity and SR were lower in CAP than in non-CAP, the average age of patients of CAP were older than non-CAP. There was no significant difference between groups with respect to blood pressure, lipids, diabetes and smoking. Conclusion Older age and lower SR are associated with carotid atherosclerosis.