解毒化瘀汤保护血管内皮细胞治疗多脏器功能障碍综合征的临床研究

Study on protective effect of Jieduhuayu decoction(解毒化瘀汤) to the vascular endothelium of multiple organ dysfunction syndrome patients

目的 :观察解毒化瘀汤对多脏器功能障碍综合征 ( MODS)患者血管内皮细胞的保护作用。方法 :40例 MODS患者随机分为西医常规治疗组 (常规组 )和西医常规治疗 +中药组 (中西药组 ) ,中药使用解毒化瘀汤2 0 0 ml/次 ,每日 2次 (患者均开放胃肠道 ) ,共服药 8日。 2组病例分别在服药当日及第 2、4、8日晨取血 ,用酶联免疫吸附法 ( EL ISA)查血管性血友病因子 ( v WF)和血栓调节蛋白 ( TM)。选取 3 0名健康自愿者 (无高血压、糖尿病、肾病等疾病 ) ,检测其 v WF和 TM值为正常对照值。结果 :常规组和中西药组 v WF、TM值均显著高于正常对照值 ( P均 <0 .0 1) ;两个指标在用解毒化瘀汤当日和第 2日组间无显著差异 ;在第 4和第 8日中西药组明显低于常规组 ( P<0 .0 5和 P<0 .0 1)。两项指标呈正相关 ,相关系数为 0 .73 0。结论 :解毒化瘀汤对 MODS患者血管内皮细胞损伤有保护作用。

Objective:To study the protective effect of Jieduhuayu decoction(解毒化瘀汤) to the vascular endothelium of multiple organ dysfunction syndrome(MODS) patients.Methods:Forty MODS patients were randomly divided into 2 groups:routine western medicine treatment group(routine group) and western medicine combined with traditional Chinese medicine treatment group(WM TCM group).In WM TCM group,patients took orally Jieduhuayu decoction 200 ml,twice per day,for 8 days.All the patients were determined the von willebrand factor(vWF) and thrombomodulin(TM) in the 1st day and the 2nd,4th,8th days.Thirty healthy volunteers(without hypertension,diabetes and kidney disease) were determined vWF and TM as normal control by emzyme linked immunosorbent assay(ELISA).Results:The vWF and TM values of routine group and WM TCM group were significantly high than the normal (all P <0 01),and there was no difference in the 1st day and the 2nd day of the 2 indexes.And they were significanty decreased in WM TCM group compared to the routine group in the 4th day and the 8th day.The 2 indexes were positive correlation,the correlative index was 0 730.Conclusions:Jieduhuayu decoction has pretective effect to the vascular endothelium of MODS patients.